Source: http://en.wikipedia.org/wiki/Best_selling_video_games#Franchise
Mario (275 million)
Pokémon (143 million)
Final Fantasy (68 million)
The Sims (58 million)
Madden NFL (51 million)
The Legend of Zelda (47 million)
Tetris (45.2 million)
Sonic the Hedgehog (44 million)
Donkey Kong (43 million)
Dragon Quest (40 million)
Grand Theft Auto (40 million)
Crash Bandicoot (39.2 million)
Gran Turismo (38 million)
James Bond (30 million)
Tomb Raider (30 million)
Resident Evil (30 million)
Tony Hawk’s Pro Skater (27.9 million)
Mega Man (26 million)
Street Fighter (25 million)
Tekken (22.7 million)
Command & Conquer (21 million)
Kirby (20.9 million)
Mortal Kombat (20 million)
FIFA (20 million)
Metal Gear (19.4 million)
Yu-Gi-Oh! (17.5 million)
Diablo (17 Million)
WWE SmackDown! (17 million)
Half-Life (16 million)
Halo (14.2 million)
Warcraft (14 million)
Harry Potter (13.2 million)
Tom Clancy’s Splinter Cell (12.5 million)
Driver (12 million)
Super Smash Bros. (11.65 million)
Metroid (11.3 million)
Battlefield (11 million)
Crash Bandicoot beat out Street Fighter, Metal Gear and Halo?
Somewhat impressive.
I read in a magazine that Brain Training is the best selling game on the DS not Nintendogs.